Exeter City Council planning committee has approved the construction of a McDonald’s restaurant on a section of unused car park beside Rydon Lane Tesco in Russell Way.
The restaurant will provide facilities for drive-through and eat-in, with 42 car parking spaces.
There were 26 public objections to the plans, which raised concerns about potential impacts including litter, odour, traffic and anti-social behaviour.
Limits on late-night opening hours will be determined separately by council licensing.